Anti-Mouse CD120a (TNFR1) (Clone 55R-170) - DyLight® 755

Tumor Necrosis Factor Receptor Type I (TNFRI) is a 55kD Type I transmembrane protein.

TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types.

TNFRI binds TNF-α and TNF-ß (also known as LT-α).

The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM), IL-6 mRNA accumulation and NF-ĸB induction.

TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein).

Binding of 55R-170 antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.