Anti-Mouse CD122 (IL-2Rβ) - Purified in vivo PLATINUM™ Functional Grade

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2,130.00 ₪

CD122 is a 70-75 kD IL-2 receptor β chain that is a type I membrane protein.

CD122 is involved in T cell-mediated immune responses and its activation increases proliferation of CD8+ effector T cells.

It exists in three forms with varying degrees of binding affinity with IL-2.

The low affinity form is a monomer of the α subunit and has no involvement in signal transduction.

The intermediate affinity form is a γ/β heterodimer and the high affinity form is an α/β/γ heterotrimer.

The intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.

This protein also interacts with the IL-15 receptor.

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Storage and Stability

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Formulation

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

Shipping Conditions

Next Day 2-8°C