Anti-Mouse IL-1α-Fluorescein

Mouse IL-1alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells.

Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties.

These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells.

However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine.