Anti-Mouse IL-1β - DyLight® 594
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IL-1R1 is an 80 kD transmembrane glycoprotein and a member of the Ig superfamily.
IL-1 binds both IL-1R1 and IL-1R2.
The ligands IL-1α and IL-1β only commence when binding IL-1R1 because IL-1R2 acts as a decoy receptor and competitively antagonizes the binding of IL-1α and IL-1β, thereby reducing their biological effects.
Binding of the ligands to IL-1R1 is enhanced by an accessory protein, IL-1R-AcP.
IL-1α can exist as either a 31 kD precursor or an 18 kD mature form.
IL-1α is a proinflammatory cell-associated cytokine and IL-1β is a 17.5 kD proinflammatory secreted cytokine.
Both IL-1α and IL-1β bind to the same receptor and have similar properties that include stimulation of thymocyte proliferation via IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells.
Furthermore, IL-1β mediates a variety of immune and inflammatory responses.
IL-1β is a major cause of severe inflammation in the mouse model of Crohn’s Disease, which makes IL-1β an important target for this disease.
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