Mouse Homeobox Protein Nkx-2.1, NKX2-1 ELI

Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor.

Crucial in the maintenance of the thyroid differentiation phenotype.

May play a role in lung development and surfactant homeostasis.

Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (PubMed: 22955271).

Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression.

Represses the transcription of the circadian transcriptional repressor NR1D1 (PubMed: 22356123).