Mouse Metabotropic Glutamate Receptor 5, GRM5 ELI

G-protein coupled receptor for glutamate.

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.

Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.

Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity (By similarity).