Porcine Glucose-6-phosphate isomerase,GPI ELI

In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity).

Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility.

Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons.

It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).

{ECO:0000250|UniProtKB:P06744, ECO:0000250|UniProtKB:P06745}.