Anti-Chikungunya Virus (Clone: CHKV-24) - Low Endotoxin Functional Formulation

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‏1,200.00 ‏₪

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics globally and has been declared a notable disease by the CDC1,2.

Symptoms include high fever, myalgia, rash, and severe polyarthritis which can persist for long after acute infection.

CHIKV is an enveloped virus with an 11.8-kb single-stranded, positive-sense RNA genome with two open reading frames3,4.

There are three main genotypes, having 95.2 to 99.8% amino acid identity: Asian, West African, and East/Central/South African (ECSA).

The mature CHIKV virion is comprised of a nucleocapsid protein C and two glycoproteins, E1 and E25.

E1 participates in virus fusion.

E2 functions in attachment to cells.

E1 and E2 form 80 trimeric spikes on the virus surface6.

Co-circulation of CHIKV with other arboviruses, such as dengue, Zika, Mayaro, and yellow fever, occurs in many countries, posing significant difficulties for diagnosis2.

Monoclonal antibodies (MAb) can be used both for diagnosis7 and as a therapeutic agent5,8,9.

CHIKV can be rapidly detected by an immunochromatographic assay using MAbs against the CHIKV envelope protein7.

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Storage and Stability

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≥ -70°C. Avoid Repeated Freeze Thaw Cycles.

Formulation

This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

Shipping Conditions

Standard Overnight on Blue Ice.