Anti-Hsc70 (Hsp73) Antibody (11119)

Hsp70 genes, members of a multigene family, encode heat-inducible 70kDa heat- shock proteins that function as molecular chaperones.

They have been identified in most organelles of eukaryotic cells as well as in bacteria.

The N-terminus of Hsp70 binds ATP with high affinity and the C- terminus binds proteins and polypeptides.

When cells are subjected to metabolic stress, Hsp70 is expressed.

Hsp70 shares >90% sequence homology with Hsc70.

Constitutively expressed Hsc70 forms a stable complex with the highly inducible Hsp70 in cells following heat shock.

This interaction is regulated by ATP.

Research on Hsc70 suggests that it plays a role in facilitating the recovery of centrosomal structure and function after heat shock.