Anti-Human CD11b - DyLight® 594
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LFA-1α (CD11a) and CD18 are the Integrin alpha-L and beta-2 chains respectively that combine to form LFA-1, a glycoprotein and a member of the Integrin family.
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3, ICAM4 and for F11R.
LFA-1 participates in the immunological synapses between CD8+ T lymphocytes and antigen-presenting cells.
The absence of LFA-1α or ß may induce LAD.
The antigen contributes to natural killer cell cytotoxicity, and is involved in various immune phenomena such as leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
The CD11b/CD18 antigen is a heterodimeric surface glycoprotein on leukocytes and belongs to the ß2 integrin family.
CD11b functions as a receptor for C3bi complement, clotting factor X, fibrinogen and ICAM-1.
CD11c forms an α/ß heterodimeric glycoprotein (CD11c/CD18 complex) which belongs to the ß2 integrin family.
The complex binds fibrinogen and reportedly serves as a receptor for iC3b and ICAM-1.
During inflammatory responses, it mediates cell to cell interaction and is important in both monocyte adhesion and chemotaxis.
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