Anti-Human Endostatin N-Terminal (a.a.1-12)

Endostatin is globular domain found at the C-terminal derived from type XVIII collagen.

It serves as an anti-angiogenic agent, similar to angiostatin and thrombospondin.

It is an angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF).

1 On the surface of endothelial cells, endostatin binds with the integrin alpha(5)beta(1) that activates the Src-kinase pathway.

The binding of endostatin with integrins also down-regulates the activity of RhoA GTPase and inhibits signaling pathways mediated by small kinases of the Ras and Raf families.

All these events promote disassembly of the actin cytoskeleton, disorders in cell-matrix interactions, and decrease in endotheliocyte mobility, i.e., promote the suppression of angiogenesis.

2 Endostatin is currently being studied as part of cancer research.