Anti-Mouse CD103 (ITGAE) - APC

CD103 integrin is a heterodimeric transmembrane receptor formed by the dimerization of αE (CD103) with β71,2.

CD103 plays a role in intestinal homeostasis and inflammation3, is a key molecule in T cell activation1, and also functions within the tumor microenvironment1.

CD103 integrin plays a role in the anti-tumor activities of tissue resident memory T cells (TRM), a type of memory T cell that is part of the adaptive immune system and also protects human epithelial tissues against inflammatory and infectious disease1.

TRM are defined by expression of CD103 and CD49a integrins and the C-type lectin CD691.

Additionally, CD103 is recruited at the immune synapse formed between cytotoxic T lymphocytes and epithelial tumor cells1, is required for polarized exocytosis of lytic granules leading to target cell lysis1, and migratory CD103+ dendritic cells are important for the initiation of cytotoxic T cell responses4.

CD103 integrin binds to E-cadherin1,2.

TGFβ increases the affinity of CD103 for E-cadherin through phosphorylation of integrin-linked kinase, induces CD103 on TCR-engaged antigen-specific CD8+ T cells, and is also directly involved in CD103 activation.

The 2E7 clone was originally used to define CD103 integrin expression in lymphocyte subsets and during T cell ontogeny5.

2E7 was shown to be reactive against CD103 integrin by immunoprecipitation.