Anti-Mouse CD120b (TNFR2) (Clone TR75-54.7) - DyLight® 488

Tumor necrosis factor receptor II (TNF-RII) or CD120b is a 75kD type I transmembrane protein present on most cell types at low levels1 including endothelial cells, cardiac myocytes and prostate cells2; the expression is upregulated upon activation.

This receptor binds both TNF-α & TNF-β (aka.

LT-α).

In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.

The TR75-54.7 antibody has been shown to block ligand-induced receptor signaling.