Anti-Mouse CD137 (4-1BB) Antibody - Purified in vivo GOLD™ Functional Grade

From

Price

720.00 ₪

4-1BB (CD137) is a 39 kD transmembrane protein that is a member of the tumor necrosis factor (TNF) receptor family and is a co-stimulatory molecule that plays a role in T-cell-mediated proliferative response.

When binding its ligand, CD137 provides costimulatory signals to both CD4 and CD8 T cells via the activation of NF-B, c-Jun and p38 downstream pathways.

Crosslinking of CD137 boosts T cell proliferation, IL-2 secretion, survival and cytolytic activity.

Furthermore, it can increase immune activity to eliminate tumors in mice.

Agonistic 4-1BB antibodies have been reported to stimulate a more intense immune system attack on cancers.

Package Size

Quantity

Storage and Stability

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Formulation

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

Shipping Conditions

Next Day 2-8°C