Anti-Mouse CD54 (Clone YN1/1.7.4) - FITC
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480.00 ₪
ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily.
It is heavily glycosylated to form 75 kDa to 115 kDa.
ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated.
The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways.
Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking.
ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies.
ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.
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