Anti-Mouse CD70 (Clone FR70) - Purified in vivo GOLD™ Functional Grade
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2,470.00 ₪
CD70, a type II transmembrane glycoprotein of the TNF family with cytokine activity, is the ligand for the CD27 receptor1.
Mouse CD70 (mCD70) has a potent co-stimulatory effect on T cell proliferation1 and acts as an immune-checkpoint2.
In mouse, but not in humans, the CD70-CD27 axis mediates a negative feedback system that enables the immune system to modulate hematopoiesis2.
Additionally, CD70-CD27 interactions are important to the formation of memory and plasma B cells.
Immunotherapies that aim to eradicate tumor cells by targeting CD70 overexpression are being developed2.
FR70 inhibits mCD70 binding to mCD27-Ig, a recombinant soluble form of mCD271, as well as to mCD27 in vitro3,4 and in vivo5. FR70 was produced by immunizing an F344/DuCrj rat with A20 cells and fusing the splenocytes with P3U1 cells to create hybridoma lines1.
HAT selection was performed, and FR70 was identified by its strong reactivity against mCD70-BHK21 cells.
Blocking with FR70 can prolong graft acceptance6,7.
When mouse cardiac allogenic graft recipients are treated with FR70, tolerogenic dendritic cells and T regulatory cells are induced, resulting in decreased cytotoxic T lymphocyte proliferation as well as long-term graft acceptance6.
Blocking with FR70 also prolongs mouse corneal graft survival7.
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