Anti-Mouse GM-CSF - Purified in vivo PLATINUM™ Functional Grade

From

Price

1,392.00 ₪

Granulocyte-Macrophage Colony Stimulating Factor is a 22 kD, pleiotropic cytokine that is a white blood cell growth factor.

It controls the production and function of blood cells by stimulating stem cells to produce granulocytes and monocytes.

GM-CSF differs from G-CSF in that it affects more cell types including macrophages and eosinophils.

Moreover, GM-CSF is part of the immune/inflammatory cascade, a process crucial for fighting infection.

Interestingly, GM-CSF expression may have pathological implications.

Autocrine expression of GM-CSF in myeloid leukemia cells is suspected to play a role in neoplasia, the formation of a new and abnormal growth of tissue.

Additionally, GM-CSF expression has also been documented in certain solid tumors.

There have also been reports of GM-CSF in synovial fluid from patients with arthritis suggesting that GM-CSF may play a role in tissue damage associated with the inflammatory process.

Blocking GM-CSF is thought to have therapeutic potential by reducing inflammation.

Some drugs are currently being developed to block GM-CSF.

Package Size

Quantity

Storage and Stability

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Formulation

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

Shipping Conditions

Next Day 2-8°C