Anti-Mouse/Human IL-5 - Biotin
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IL-5 is a 26 kD TH2 cytokine and a homodimeric glycoprotein that is part of the hematopoietic family.
IL-5 stimulates B cell growth as well as increases Ig secretion.
It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils.
IL-5 is a major regulator of eosinophil accumulation in tissues.
In fact, in Hodgkin lymphoma, the characteristically observed eosinophilia is suspected to result from an increased production of IL-5.
IL-5 may also be the cause of several allergic diseases including asthma, where it is thought that eosinophils have a significant role in the disease pathology.
There are several mAbs currently in use that target IL-5 for the treatment of severe eosinophilic asthma.
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