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Anti-Mouse IL-1 R1, Type 1-Biotin
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₪475.60
IL-1 binds two receptors, IL-1RI and IL-1RII.
The ligands IL-1α and IL-1ß exert all of their various biological actions by binding IL-1RI.
IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1α and IL-1ß, thereby reducing their biological effects.
Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP.
IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells.
It is an 80 kD transmembrane glycoprotein.
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Storage and Stability
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
Formulation
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Shipping Conditions
Next Day Ambient
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