Anti-Mouse IL-4 - Purified in vivo GOLD™ Functional Grade

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1,480.00 ₪

IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells.

It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses.

Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4.

Increased IL-4 production and overproduction of IL-4R are found in many cancers.

IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement.

IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.

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Storage and Stability

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Formulation

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

Shipping Conditions

Next Day 2-8°C