Anti-Rabies Virus Antibody (20501)

Rabies is a zoonotic infectious disease of the central nervous system.

In unvaccinated or untreated subjects, rabies virus infection causes severe neurological symptoms and is usually fatal.

Rabies virus has a bullet-shaped, enveloped virion with a negative-sense single-stranded RNA genome that encodes five viral proteins: nucleoprotein, phosphoprotein, matrix protein, glycoprotein, and RNA-dependent RNA polymerase.

The virus attaches to its cellular targets by the surface glycoprotein (RABV-G), rapidly gains access to peripheral nerves, and ultimately reaches the brain.

Transport of the enveloped virus within nerve cells and neuronal transport vesicles impedes clearance by humoral or cellular immunity.