Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP2-F6) - Biotin
2,450.00 ₪
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
SARS-CoV-2 belongs to the Coronaviridae family, and its single-stranded, positive-sense RNA genome shares 79.6% identity with SARS-CoV1.
The spike (S), envelope (E), membrane (M), and nucleocapsid proteins (N) are four essential structural proteins of SARS-CoV-22.
The 46 kDa N protein is highly conserved and shares 90% homology with SARS-CoV3.
Similar to SARS-CoV, SARS-CoV-2 has an N-terminal (NTD) and C-terminal domain (CTD), linked by a linker region.
The NTD binds to RNA, while the CTD self-oligomerizes4,5, aiding viral genome packaging into a helical ribonucleoprotein complex6.
The N protein also participates in viral transcription, replication, and modulation of cell signaling pathways7,8.
Some vaccine and diagnostic assays9 have focused on the N protein as it is highly expressed during infection and activates antibodies3,10 and memory T cells11,12, found in convalescent sera.
The N-protein also evades the innate immune system by inhibiting RNAi13, identifying it as a potential therapeutic target.
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