Bovine Complement C5,C5 ELI

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process.

Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes.

C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

{ECO:0000250|UniProtKB:P01031}.