Bovine Integrin Alpha-L, ITGAL ELI

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4.

Integrin ITGAL/ITGB2 is a receptor for F11R.

Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL.

Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

Contributes to natural killer cell cytotoxicity.

Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils.

Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis.

Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.