Bovine Legumain, LGMN ELI

Has a strict specificity for hydrolysis of asparaginyl bonds.

Can also cleave aspartyl bonds slowly, especially under acidic conditions.

Required for normal degradation of internalized EGFR.

Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules.

May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.