Bovine Myeloid Differentiation Primary Response Protein Myd88, MYD88 ELI

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.

Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Increases IL-8 transcription.

Involved in IL-18-mediated signaling pathway.

Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (PubMed: 17936907, PubMed: 18760477).

MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).