Bovine Smarcc1 ELI

Core component of the BAF (SWI/SNF) complex.

This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation.

The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal.

This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers.

Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A.

Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.

Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).

During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.

The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.

As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).

The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.

The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).