Bovine Sorbitol Dehydrogenase, SDH ELI

Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols.

Is mostly active with xylitol, D-sorbitol (D-glucitol) and L-iditol as substrates, leading to the C2-oxidized products D-xylulose, D-fructose and L-sorbose, respectively (PubMed: 9143345).

Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism.

May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity).

Cannot use NADP(+) as the electron acceptor.

Has no activity on ethanol, methanol, glycerol, galactitol and fructose 6-phosphate (PubMed: 9143345).