Canine Vascular Cell Adhesion Molecule 1, VCAM-1 ELI

Important in cell-cell recognition.

Appears to function in leukocyte-endothelial cell adhesion.

Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction.

The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation (By similarity).