Chicken desmin,Des ELI

Muscle-specific type III intermediate filament essential for proper muscular structure and function.

Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity.

In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.

{ECO:0000250|UniProtKB:P17661, ECO:0000250|UniProtKB:P31001}.