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Human 2-oxoglutarate dehydrogenase complex component E1,OGDH ELI

Price

‏3,140.00 ‏₪

2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate (PubMed:24495017).

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:24495017).

The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711).

A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).

{ECO:0000269|PubMed:24495017, ECO:0000269|PubMed:29211711}.

Package Size

Quantity

Storage and Stability

2-8ºC

Sensitivity

0.41ng/ml

Detection range

0.75-48ng/ml

Shipping Conditions

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