Human 5-Hydroxytryptamine Receptor 1A, HTR1A ELI

G-protein coupled receptor for 5-hydroxytryptamine (serotonin).

Also functions as a receptor for various drugs and psychoactive substances.

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.

Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.

Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores.

Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism.

Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior.

Plays a role in the response to anxiogenic stimuli.