Human A Disintegrin And Metalloprotease 15,ADAM15 ELI
3,140.00 ₪
Active metalloproteinase with gelatinolytic and collagenolytic activity.
Plays a role in the wound healing process.
Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation.
Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells.
Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation.
Cleaves E-cadherin in response to growth factor deprivation.
Plays a role in glomerular cell migration.
Plays a role in pathological neovascularization.
May play a role in cartilage remodeling.
May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction.
May play a role in sperm-egg binding through its disintegrin domain.
{ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}.
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