Human Acetyl-CoA Carboxylase 1, ACACA ELI

Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed: 20952656, PubMed: 20457939, PubMed: 29899443).

This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed: 20952656, PubMed: 20457939, PubMed: 29899443).