Human Acid Sphingomyelinase-like Phosphodiesterase 3B, SMPDL3B ELI

Lipid-modulating phosphodiesterase (PubMed: 26095358).

Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity.

Acts as a negative regulator of Toll-like receptor signaling (By similarity).

Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed: 26095358).

Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity).