Human Acidic leucine-rich nuclear phosphoprotein 32 family member E,ANP32E ELI

Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions.

Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome.

May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511).

Inhibits activity of protein phosphatase 2A (PP2A).

Does not inhibit protein phosphatase 1.

May play a role in cerebellar development and synaptogenesis.

{ECO:0000269|PubMed:24463511}.