Human Activated Leukocyte Cell Adhesion Molecule, ALCAM ELI

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network.

Required for normal hematopoietic stem cell engraftment in the bone marrow.

Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow.

Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM.

Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). Inhibits activities of membrane-bound isoforms by competing for the same interaction partners.

Inhibits cell attachment via homotypic interactions.

Promotes endothelial cell migration.

Inhibits endothelial cell tube formation.