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Human Activation-induced cytidine deaminase,AICDA ELI

Price

‏3,140.00 ‏₪

Single-stranded DNA-specific cytidine deaminase.

Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA.

Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525).

May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).

{ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21518874, ECO:0000269|PubMed:27716525}.

Package Size

Quantity

Storage and Stability

2-8ºC

Sensitivity

0.13mIU/L

Detection range

0.2-60mIU/L

Shipping Conditions

Next Day Ambient
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