Human Adapter Molecule Crk, CRK ELI

Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.

[Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed: 31311869).

Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner.

Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed: 19004829).

May regulate the EFNA5-EPHA3 signaling (By similarity).