Human Adenosine Deaminase, ADA ELI

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed: 8452534, PubMed: 16670267).

Plays an important role in purine metabolism and in adenosine homeostasis.

Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events.

Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed: 20959412).

Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed: 11772392).

Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity).

Enhances CD4+ T-cell differentiation and proliferation (PubMed: 20959412).

Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed: 23193172).

Stimulates plasminogen activation (PubMed: 15016824).

Plays a role in male fertility (PubMed: 21919946, PubMed: 26166670).

Plays a protective role in early postimplantation embryonic development (By similarity).