Human Adp-Ribosylation Factor 6, ARF6 ELI

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed: 11266366, PubMed: 21170023, PubMed: 16737952, PubMed: 7589240, PubMed: 18400762).

Required for normal completion of mitotic cytokinesis (By similarity).

Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity).

Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed: 14978216).

Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization.

Regulates surface levels of adherens junction proteins such as CDH1 (By similarity).

Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity).

(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.