Human Amyloid-like Protein 1, APLP1 ELI

May play a role in postsynaptic function.

The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity).

Couples to JIP signal transduction through C-terminal binding.

May interact with cellular G-protein signaling pathways.

Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.

The gamma-CTF Peptide, C30, is a potent enhancer of neuronal apoptosis.