Human Angiopoietin-related Protein 7, ANGPTL7 ELI

Has a role in the formation and organization of the extracellular matrix.

In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed: 21199193).

Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed: 25622036).