Human Angiotensin Converting Enzyme, ACE ELI

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin.

Also able to inactivate bradykinin, a potent vasodilator.

Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.