Human Annexin A1, ANXA1 ELI

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process.

Has anti-inflammatory activity (PubMed: 8425544).

Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity).

Promotes resolution of inflammation and wound healing (PubMed: 25664854).

Functions at least in part by activating the formyl Peptide receptors and downstream signaling cascades (PubMed: 15187149, PubMed: 25664854).

Promotes chemotaxis of granulocytes and monocytes via activation of the formyl Peptide receptors (PubMed: 15187149).

Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed: 17008549).

Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed: 17008549).

Has no effect on unstimulated T cells (PubMed: 17008549).

Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed: 15187149).

Negatively regulates hormone exocytosis via activation of the formyl Peptide receptors and reorganization of the actin cytoskeleton (PubMed: 19625660).

Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity).

Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed: 2532504, PubMed: 8557678).

Plays a role in the formation of phagocytic cups and phagosomes.

Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).