Human Annexin A2, ANXA2 ELI

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids.

It binds two calcium ions with high affinity.

May be involved in heat-stress response.

Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed: 18799$458.00|$300.00, PubMed: 24808179, PubMed: 22848640).