Human Anoctamin 1, ANO1 ELI

Calcium-activated chloride Channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction.

Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles.

Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.