Human Aspartyl/Asparaginyl Beta-hydroxylase, ASPH ELI

[Isoform 1]: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.

[Isoform 8]: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions.

Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) Channels in T-cells.