Human Astacin Like Metallo Endopeptidase, ASTL ELI

Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization.

Plays a role in the polyspermy inhibition.

Probably acts as a protease for the post-fertilization cleavage of ZP2.

Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity).