Human B-Cell CLL;Lymphoma 11A,Bcl11A;Ctip1 ELI
3,140.00 ₪
Transcription factor (PubMed:16704730, PubMed:29606353).
Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491).
Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353).
Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765).
Involved in brain development (PubMed:27453576).
May play a role in hematopoiesis (By similarity).
Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity).
May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity).
{ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}.
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